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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUWE1 All Species: 19.09
Human Site: S620 Identified Species: 52.5
UniProt: Q7Z6Z7 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z6Z7 NP_113584.3 4374 481891 S620 L N A R G L Q S F V Q C Q P F
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001088987 4374 481661 S620 L N A R G L Q S F V Q C Q P F
Dog Lupus familis XP_538052 4375 482124 S620 L N A R G L Q S F V Q C Q P F
Cat Felis silvestris
Mouse Mus musculus Q7TMY8 4377 482644 S620 L N A R G L Q S F V Q C Q P F
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923899 4360 479137 S620 L N A R G L H S F V Q C Q P F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573059 5146 556842 E739 L N E R G L F E F L S Y D P F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_500284 4177 465393 T634 H Q S A H L I T N F V Y Q F P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GY23 3681 404981 K231 S D L E L L N K L V I D H N V
Baker's Yeast Sacchar. cerevisiae Q03280 3268 374166
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.6 98.7 N.A. 97.7 N.A. N.A. N.A. N.A. N.A. 81.6 N.A. 33.7 N.A. 26.2 N.A.
Protein Similarity: 100 N.A. 99.7 99.1 N.A. 98.6 N.A. N.A. N.A. N.A. N.A. 88.4 N.A. 48.4 N.A. 44.3 N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 100 N.A. N.A. N.A. N.A. N.A. 93.3 N.A. 53.3 N.A. 13.3 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 N.A. N.A. N.A. N.A. N.A. 93.3 N.A. 60 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.4 21.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41.1 38.3 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 56 12 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 56 0 0 0 % C
% Asp: 0 12 0 0 0 0 0 0 0 0 0 12 12 0 0 % D
% Glu: 0 0 12 12 0 0 0 12 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 12 0 67 12 0 0 0 12 67 % F
% Gly: 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 % G
% His: 12 0 0 0 12 0 12 0 0 0 0 0 12 0 0 % H
% Ile: 0 0 0 0 0 0 12 0 0 0 12 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % K
% Leu: 67 0 12 0 12 89 0 0 12 12 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 67 0 0 0 0 12 0 12 0 0 0 0 12 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 67 12 % P
% Gln: 0 12 0 0 0 0 45 0 0 0 56 0 67 0 0 % Q
% Arg: 0 0 0 67 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 12 0 12 0 0 0 0 56 0 0 12 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 67 12 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 23 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _